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Fernanda Teresa Lima

Universidade Federal de São Paulo

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AUG 12, 2026 · JOURNAL ARTICLE

Next-Generation Sequencing Refines Diagnosis and Expands Precision Medicine Opportunities in Soft Tissue Sarcomas

International Journal of Molecular Sciences

Retrospective single-centre biobank study of NGS diagnostic utility in a small, heterogeneous cohort without a prospective validation arm, comparator cohort, or clinical outcome data; demonstrates feasibility and diagnostic reclassification but lacks the rigor needed to claim practice change.

PreliminaryFrancine Tesser‐Gamba Thais Biude Mendes Eliana Maria Monteiro Caran

Reported

Clinically relevant alterations d…70% (37/55)

Fusion transcripts18

Single nucleotide variants13

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