SEP 2, 2026 · JOURNAL ARTICLE
Subtyping metabolic dysfunction-associated steatotic liver disease using electronic health record-linked genomic cohorts reveals diverse etiologies and progression
Nature Communications
A well-designed latent class analysis identifying five reproducible MASLD subtypes with distinct genetic and clinical profiles in independent cohorts, but a cross-sectional observational study without prospective clinical trials or hard outcome validation.
Reported
Number of MASLD subtypes identifi…5
Subgroup C4 liver transplant ratehighest rate
Subgroup C4 ischemic heart diseas…lowest incidence