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Magdalena Bofill Rodriguez

University of Auckland

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SEP 4, 2026 · JOURNAL ARTICLE

Long-term hormone therapy for perimenopausal and postmenopausal women

Cochrane Database of Systematic Reviews

High-quality systematic review of 24 RCTs (45,660 participants) with moderate certainty evidence on long-term hormone therapy effects across multiple clinical outcomes; primarily powered by two well-conducted large trials (HERS, WHI) with low risk of bias.

Strong EvidenceLi Ning Yong Cindy Farquhar Christine Bekos

Reported

Sample size45660

Combined HT – Coronary events (RR)1.17

Combined HT – Coronary events (95…0.95 to 1.44

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