AUG 17, 2026 · PHASE 1 TRIAL
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
ClinicalTrials.gov
This is a Phase 1 mechanistic imaging study in active recruitment with no results posted; it aims to establish whether PDE4B is reduced in MDD brains using a novel radioligand, representing early-phase exploratory work.
Reported
Planned enrollment108
Study phasePHASE 1
Primary outcome measureDistribution volume of [18F]PF-06445974 at…