DEC 29, 2025 · JOURNAL ARTICLE
Blautia coccoides-derived metabolite trimethylamine-N-oxide exacerbates Alzheimer's disease progression via targeting HIF1α signaling.
Gut Microbes
Mechanistic study in animal models and cell cultures with observational human data; identifies a putative pathway but lacks clinical outcome validation or human intervention trials needed for stronger evidence.
Reported
Human cohort size22
HIF1α binding site235–238