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Ute Schmitt

Johannes Gutenberg University Mainz

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JUL 28, 2026 · JOURNAL ARTICLE

MCT4 loss reprograms MC38 tumor environment and potentiates mRNA cancer-vaccine therapy 2305984

The Journal of Immunology

A mechanistic preclinical study in syngeneic mouse tumors demonstrating that MCT4 knockout enhances mRNA vaccine efficacy through immune microenvironment reprogramming, requiring confirmation in larger models and clinical translation.

PromisingElena Klein Fulvia Vascotto Yasemin Ahrberg

Reported

Tumor growthreduced in MC38 Mct4-KO versus wild-type in…

Rejection rateincreased in MC38 Mct4-KO in immunocompeten…

Minimal tumor differencesobserved in immunodeficient mice

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