AUG 25, 2026 · JOURNAL ARTICLE
Gut microbial diversity at baseline conditions the clinical, microbiome, and metabolic response to paraprobiotic Lactiplantibacillus plantarum LRCC5282 in overweight adults.
Gut Microbes
A well-designed RCT showing no overall effect, but a pre-specified subgroup analysis (low baseline microbial diversity) demonstrated significant clinical improvements with mechanistic support from microbiome and metabolite data; requires confirmation in a prospective, diversity-stratified trial.
Reported
Sample size120
Trial duration12 weeks
Overall population between-group…no significant differences