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Yaonan Song

Tongji Hospital

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SEP 2, 2026 · JOURNAL ARTICLE

NRF2 activation attenuates obesity-induced adipose inflammation by suppressing STING signaling, with depot-specific regulation

Journal of Translational Medicine

Mechanistically rigorous preclinical study with in vitro and in vivo evidence in mouse models showing NRF2 activation suppresses obesity-related inflammation via STING inhibition, but lacks human data and clinical endpoints needed for stronger evidence grade.

PromisingLin Zhao Huipeng Wang Xiaoying Zhai

Reported

NRF2 activity status in obese WATreduced

Pharmacological NRF2 activation e…significantly improved

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