JUL 28, 2026 · JOURNAL ARTICLE
Longitudinal comparative performance of triglyceride-glucose-related indices and estimated glucose disposal rate for predicting metabolic syndrome risk.
Journal of Diabetes and Metabolic Disorders
Prospective cohort with robust methodology (Cox models, time-dependent ROC, C-index, NRI/IDI) demonstrates TYG-WC as superior predictor of metabolic syndrome incidence with clinically meaningful effect size and excellent discrimination (C-index 0.83) across stratified subgroups.
Reported
Primary endpoint – aHR per SD1.44 (95% CI [1.24–1.66])
Risk at threshold >775.92.65-fold increased risk
Harrell's C-index0.83