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EUGENE AMPOFO

Kwame Nkrumah University of Science and Technology

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SEP 6, 2026 · REVIEW

A Systematic Review and Meta‐Analysis of Malnutrition and Metabolic Failure in High‐Potency Incretin Therapy

Obesity Science & Practice

Rigorous meta-analysis of 19 randomized trials using GRADE methodology and Cochrane risk-of-bias assessment, revealing a substantial discrepancy between reported and objective nutritional markers that should inform clinical monitoring practice.

Strong EvidencePharmacology and Obesity Treatment Charles Apprey Mary Amoako

Reported

Daily energy intake decline range24.00%–39.20%

Model-estimated daily energy defi…1200 kcal

Fat-free mass reduction (tirzepat…1.60 kg

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