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Alexandre Xu-Vuillard

Institut Gustave Roussy

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SEP 9, 2026 · REVIEW

Randomised phase III trials of cancer prevention drugs: a systematic review and prediction of trial success

ESMO Open

A rigorous systematic review of 92 phase III RCTs over 45 years with 659,904 participants, using prespecified definitions of success and multivariable logistic regression to identify predictors of trial outcomes in cancer prevention.

Strong EvidenceBRCA Gene Mutations in Cancer Bruno Duso Judith Balmañà

Reported

Success rate by class: vaccines8 of 9 (88.9%)

Success rate by class: endocrine…15 of 20 (75.0%)

Success rate by class: NSAIDs8 of 13 (61.5%)

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