AUG 8, 2026 · JOURNAL ARTICLE
Radiation Therapy and Overall Survival in Perineural Invasion–Positive Cutaneous Squamous Cell Carcinoma of the Head and Neck: A National Cancer Database Analysis
Head & Neck
Retrospective cohort study from a large national registry with clear methodology and a clinically relevant finding (RT may improve OS in PNI-positive cSCC), but susceptible to confounding by indication and limited by observational design; prospective validation is needed.
Reported
Sample size929
PNI-positive patients276
PNI-negative patients653