JUN 21, 2026 · JOURNAL ARTICLE
The IL-17A/Neutrophil axis plays a critical role in lethal infection induced by an emerging ultra-virulent Streptococcus suis serotype 5 strain.
Virulence
Mechanistic study in a mouse model of emerging pathogen infection identifies IL-17A/neutrophil axis as a therapeutic target, with functional evidence from blocking and depletion experiments showing reduced mortality, but limited by single-strain preclinical design without human efficacy data.
Reported
Mortality reduction with IL-17A b…effective reduction at infection stages 1 a…
Bacterial burden after neutrophil…significantly reduced
Dose–response relationshipdose-dependent protection observed