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Akash Patil

Johns Hopkins University

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SEP 10, 2026 · JOURNAL ARTICLE

Quantitative Systems Pharmacology Model Predicts Enhanced Antitumor Efficacy of Combined Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) Blockade in a Syngeneic Mouse Model of Breast Cancer

Acs Pharmacology & Translational Science

A mechanistic computational model of checkpoint-inhibitor combinations in mice that predicts synergy but lacks experimental validation of the proposed mechanisms in humans and does not address clinical efficacy or safety.

Hypothesis-GeneratingTheinmozhi Arulraj Aleksander S. Popel Vaccines and Immunoinformatics Approaches

Reported

Reciprocal potency synergyapproximately 4-fold

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