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G. Mercier

University of Saskatchewan

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AUG 8, 2026 · JOURNAL ARTICLE

Restoration of chemosensitivity to drug resistant breast cancer cells through peptide activation of the anaphase promoting complex

Scientific Reports

A single-arm, proof-of-concept study in cell lines and one mouse model showing mechanistic restoration of chemosensitivity in a drug-resistant breast cancer line, with clear biological signals but lacking comparative controls and human efficacy data.

PromisingS. Valentine T. A. A. Harkness R. E. Harris

Reported

Cell line testedMDA-MB-231 (human breast cancer)

Model systemsIn vitro cell assays and in vivo mouse model

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