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Researcher

Hang Chu

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China.

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AUG 4, 2026 · JOURNAL ARTICLE

Loss of EGFR activity in skeletal stem/progenitor cells is associated with impaired fracture healing in aged mice.

Bioactive Materials

Sound mechanistic study in aged mice using genetic models and a novel hydrogel intervention showing accelerated fracture healing, but limited to preclinical animal work without human efficacy data or clinical trial evidence.

PromisingYulong Wei Yi Wang Yangyang Chen

Study details

DesignPreclinical mechanistic and intervention st…

InterventionStem/progenitor-specific EGFR overactivatio…

ComparatorEgfr iCKO (loss-of-function) model and age-…

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