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Hiroki Goto

Kumamoto University Hospital

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AUG 11, 2026 · JOURNAL ARTICLE

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Scientific Reports

Retrospective observational study of 161 patients suggesting dose modifications do not compromise survival in second-line pancreatic cancer, but lacks randomization and prospective design to establish definitive practice guidance.

PromisingYujiro Ueda Cholangiocarcinoma and Gallbladder Cancer Studies Mototsugu Shimokawa

Reported

Overall survival (standard vs. re…8.1 vs. 8.8 months

Hazard ratio (standard vs. reduce…1.15

p-value (standard vs. reduced dos…0.47

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