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Meta-analysis of 27 fMRI studies with 561 patients showing differential neural mechanisms between psychotherapy and pharmacotherapy in anxiety disorders, but findings are explicitly described as exploratory due to limited and heterogeneous evidence base.
Systematic review of 20 small pharmacotherapy trials showing bupropion, SSRIs, and opioid antagonists with preliminary promise, but limited by few RCTs, small samples, and short follow-up, insufficient for practice-changing recommendations.