SEP 5, 2026 · JOURNAL ARTICLE
Lactational Enrofloxacin Exposure Promotes Offspring Lipid Metabolic Disorder and Adiposity Involving Gut Microbiota-Derived LPS and PPARγ Signaling
Microorganisms
A mechanistic study in mouse models with in vitro validation, demonstrating a plausible pathway but lacking human data, clinical hard endpoints, or definitive proof of causation in the proposed mechanism.
Reported
Mechanism of adipose expansionAdipocyte hyperplasia
Bacterial taxa alteredIncreased Gram-negative Proteobacteria
Circulating LPS statusElevated (systemic endotoxemia)