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Claudio Laudani

Policlinico Universitario di Catania

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AUG 26, 2026 · JOURNAL ARTICLE

Catheter-Based Left Atrial Appendage Closure vs Oral Anticoagulation in Patients With Atrial Fibrillation

JAMA Cardiology

High-quality meta-analysis of 8 RCTs with 7434 patients and 37.9-month follow-up reporting hard clinical endpoints (stroke, major bleeding) with precise effect estimates and confidence intervals, demonstrating no superiority of LAAC over OAC and a higher ischemic stroke risk.

Strong EvidenceDavide Capodanno Daniele Giacoppo Luigi Cutore

Reported

Sample size7434

Number of trials8

Weighted mean follow-up37.9 months

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