Colorectal Cancer

SEP 4, 2026 · PHASE 1 TRIAL

A Study of [177Lu]Lu-A9-0631 and [225Ac]Ac-A9-0642 With [68Ga]Ga-A9-6217 or [177Lu]Lu-A9-0631 Imaging in GRPR+ Solid Tumors

ClinicalTrials.gov

Phase 1 trial in early recruitment with no results posted; addresses safety, tolerability, and dose-finding in a novel radiopharmaceutical setting.

AUG 24, 2026 · JOURNAL ARTICLE

Body mass index and dyslipidemia influence responses to anti-PD-1 immunotherapy in colorectal cancer.

Annals of Medicine

A retrospective single-centre cohort study identifies BMI and dyslipidemia as associations with improved PFS in anti-PD-1-treated CRC, supported by exploratory lipidomic profiling, but lacks a control arm and prospective design to establish causation or clinical utility.

AUG 18, 2026 · OBSERVATIONAL STUDY

Evaluation for NCI Surgery Branch Clinical Research Protocols

ClinicalTrials.gov

This is an ongoing observational screening registry with no posted results; it describes planned enrollment and evaluation procedures for experimental immunotherapy protocols, not outcome data.

AUG 14, 2026 · PHASE 1 TRIAL

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

ClinicalTrials.gov

Phase 1 trial of a novel combination of KRAS-targeted TCR-engineered T-cells with therapeutic vaccine in metastatic solid cancers; registry record with no results posted; early-stage feasibility and safety assessment.

AUG 10, 2026 · INTERVENTIONAL STUDY

Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics

ClinicalTrials.gov

This is a registry record for an ongoing interventional study with no reported results; enrollment is estimated at 1000 but completion and outcome data are not yet available.

JUL 26, 2026 · JOURNAL ARTICLE

Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer.

Cancer Biology & Therapy

This is a narrative review synthesizing existing knowledge about molecular pathways in colorectal cancer and therapeutic strategies, without presenting new primary data, clinical trials, or original findings to evaluate.

MAY 26, 2026 · JOURNAL ARTICLE

The "oral-gut axis" transmission of microorganisms in colorectal cancer: Insights from Peptostreptococcus' perspective.

Virulence

This is a narrative review synthesizing emerging evidence on the oral-gut axis and Peptostreptococcus in colorectal cancer, presenting mechanistic hypotheses and research perspectives rather than original empirical findings or definitive clinical evidence.

MAY 16, 2026 · JOURNAL ARTICLE

An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer.

Oncoimmunology

Preclinical organoid-based mouse model study demonstrating proof-of-concept for CD8+ T cell dysfunction characterization and ICI responsiveness, lacking direct clinical validation or comparative efficacy trials.