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S Espiard

Université de Lille

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AUG 11, 2026 · JOURNAL ARTICLE

Impact of adrenalectomy on metabolic alterations and quality of life in mild autonomous cortisol secretion: results from the randomized CHIRACIC trial

European Journal of Endocrinology

A rigorous multicenter RCT with adequate follow-up that confirms prior findings but shows adrenalectomy offers limited benefit beyond hypertension for metabolic and QoL outcomes in MACS, with wide confidence intervals and modest effect sizes.

Important Confirmatory EvidenceHormonal Regulation and Hypertension Adrenal and Paraganglionic Tumors Laurence Amar

Reported

Sample size (adrenalectomy)23

Sample size (conservative managem…25

Weight loss >5% (adrenalectomy)21%

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