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Jan F de Leijer

Department of Vascular Medicine & Endocrinology, University Medical Center Utrecht, Utrecht, the Netherlands.

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APR 17, 2026 · JOURNAL ARTICLE

Impact of risk factor burden and vascular bed involvement on dementia risk in individuals with established cardiovascular disease.

American Journal of Preventive Cardiology

Prospective cohort study demonstrating dose-dependent associations between CVD risk factor burden, multi-bed vascular disease, and dementia incidence with adjusted hazard ratios and confidence intervals, supporting existing mechanistic understanding but lacking intervention data.

Important Confirmatory EvidenceDementia Cardiovascular Disease Tessa A C M Vissers

Reported

Sample size10321

Dementia events296

Median follow-up10.1 years

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