JUN 19, 2026 · JOURNAL ARTICLE
Amyloid-β1-42 oligomers compromise oligodendrocyte precursor cells and disrupt blood-brain barrier integrity in vitro.
Brain Research
In vitro mechanistic study demonstrating Aβ1-42 effects on glial and vascular cells; lacks in vivo validation and clinical outcome data, limiting immediate translational impact.
Reported
Aβ isoform specificityAβ1-42 induced cytotoxicity; Aβ1-40 did not
Cell types affectedOPCs and PCs showed cytotoxicity; ECs showe…
Upregulated genes in Aβ1-42-treat…Mmp9, Il1b