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AUG 14, 2026 · JOURNAL ARTICLE

Antipsychotic medication and the prevention of psychiatric emergencies in difficult-to-treat adolescent depression.

Journal of Affective Disorders

Large observational cohort study with propensity-score weighting comparing antipsychotics to antidepressants for a hard clinical outcome (psychiatric emergency visits/admissions) in adolescents with difficult-to-treat depression, showing increased risk with antipsychotics and consistent results across sensitivity analyses.

Strong EvidencePatrick D Quinn Tanya E Froehlich Richard F Meraz

Reported

Hazard ratio (antipsychotic vs. a…1.59

95% CI for hazard ratio1.46, 1.72

Cumulative incidence, antipsychot…38.7%

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