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Jian Ma

Harbin Medical University

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AUG 11, 2026 · JOURNAL ARTICLE

Inhibiting menin attenuates high-fat diet-induced weight gain by limiting intestinal lipid absorption in mice

Journal of Clinical Investigation

A mechanistically rigorous preclinical study demonstrating that menin inhibition reduces high-fat diet-induced weight gain in mice through intestinal lipid absorption limitation, supported by organoid validation but lacking human efficacy data.

PromisingXiaoru Cao Yan Cao Zhitao Guo

Reported

Primary findingMen1 deficiency protected against high-fat…

Molecular mechanismCES1 expression elevated; triglyceride hydr…

Drug validationMI-463 recapitulated metabolic effects of M…

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