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Guo Chang

Chinese Academy of Medical Sciences & Peking Union Medical College

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AUG 13, 2026 · JOURNAL ARTICLE

MMP14-engineered biomimetic nanodrug for intratumoral antibacterial therapy suppresses colorectal cancer growth and liver metastasis

Journal of Nanobiotechnology

Early-stage preclinical study demonstrating proof-of-concept for a novel nanodrug in mouse models of colorectal cancer; no human efficacy data, clinical outcomes, or comparative efficacy trial provided.

PreliminaryQianyi Ming Rui Guo Zhiwen Lin

Reported

Primary outcome measureSubcutaneous tumor growth and liver metasta…

Immune response markerEnhanced CD8+ T-cell infiltration

Bacterial burdenDecreased intratumoral Fn signals

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