SEP 1, 2026 · JOURNAL ARTICLE
Brca1 heterozygosity leads to hepatic steatosis in male and female mice despite sexually dimorphic effects on systemic metabolism
Metabolism
A well-designed preclinical study with mechanistic depth and human genetic support, but limited to mouse models and surrogate endpoints; findings require clinical validation.
Study details
DesignControlled preclinical longitudinal study w…
InterventionHigh-fat diet; tirzepatide (dual GLP-1/GIP…
ComparatorLow-fat diet; wild-type littermates; untrea…