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Michel M. van den Heuvel

Radboud University Nijmegen

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AUG 15, 2026 · JOURNAL ARTICLE

Pre-treatment T cell phospho-signalling identifies clinical pembrolizumab response in non-small cell lung cancer patients

International Immunopharmacology

A single-centre, exploratory biomarker study with moderate sample size showing an association between ex vivo T cell phospho-signalling and overall survival (HR 2.83, p=0.013), but requiring validation in independent cohorts before clinical application.

PromisingRuben L. Smeets Radiomics and Machine Learning in Medical Imaging E. van Rijssen

Reported

Sample size64

Hazard ratio for optimal versus l…2.83

p-value for overall survival diff…0.013

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