JUL 28, 2026 · JOURNAL ARTICLE
Unravelling gene regulatory networks and driver TFs in CD4+ regulatory T cell development in the human thymus 2308489
The Journal of Immunology
Single-cell mechanistic study identifying transcription factor networks in thymic Treg development with CRISPR validation in primary cells, but lacks clinical outcomes or disease models needed to establish therapeutic relevance.
Study details
DesignSingle-cell multiome atlas with CRISPR-Cas9…
InterventionCRISPR-Cas9 knockout of candidate transcrip…
ComparatorComparison of gene regulatory networks betw…