Bone Metabolism and Diseases

SEP 7, 2026 · JOURNAL ARTICLE

Context-dependent roles of the NLRP3 inflammasome in osteomyelitis and strategies for precision modulation

Frontiers in Immunology

This is a mechanistic review synthesizing existing knowledge about NLRP3 inflammasome roles in osteomyelitis pathogenesis and proposing therapeutic strategies, without reporting new experimental or clinical trial data.

SEP 7, 2026 · JOURNAL ARTICLE

RUNX2 inhibitor CADD522 improves bone microarchitecture and lipid metabolism in post-menopausal bone loss

npj Drug Discovery.

Preclinical mechanistic study in an animal model with no clinical trial data, demonstrating target engagement and a potential therapeutic approach requiring confirmation in human subjects.

AUG 24, 2026 · JOURNAL ARTICLE

Integrated multi-omics analysis and functional experiments reveals PPAP2C as a potential prognostic biomarker and therapeutic target in breast cancer

Frontiers in Pharmacology

Integrative multi-omics study with confirmatory survival analyses across multiple cohorts and mechanistic validation in TNBC cells and xenografts, but lacks clinical trial evidence and therapeutic efficacy data in vivo.

AUG 17, 2026 · JOURNAL ARTICLE

Glucose metabolism in osteoporosis: A potential therapeutic target (Review)

International Journal of Molecular Medicine

This is a narrative review synthesizing mechanistic evidence and pathophysiological theory about glucose metabolism in osteoporosis, proposing insulin signaling as a therapeutic target without reporting clinical trial data or direct evidence of efficacy.