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Thomas Eder

University of Veterinary Medicine Vienna

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AUG 18, 2026 · JOURNAL ARTICLE

Mutant TP53 allelic states in human hematopoietic stem and progenitor cells

Leukemia

In vitro CRISPR-engineered model system in cord blood HSPCs demonstrating differential effects of TP53 allelic states on colony formation and chromosomal instability, but lacking clinical outcome data or in vivo validation.

PreliminaryK. Lind Cancer Related Molecular Pathways Acute Myeloid Leukemia Research

Reported

Integration efficiency0.5–10.0%, mean 2.23 ± 1.76 SD

CFU passage retentionBiallelic aberrations elevated through pass…

Statistical significance for bial…P < 0.0001

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