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Minahil Ali

Allama Iqbal Medical College

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AUG 17, 2026 · REVIEW

Efficacy and safety of carboplatin-containing chemotherapy in triple-negative breast cancer: A comprehensive systematic review, meta-analysis, and trial sequential analysis with BRCA/HRD subgroup assessment

Journal of Oncology Pharmacy Practice

High-quality meta-analysis of 23 Phase II/III RCTs (n=8797) demonstrating clinically meaningful improvements in DFS, OS, and pCR with carboplatin-containing chemotherapy in TNBC, with rigorous pooling and quantified safety trade-offs.

Strong EvidenceMuaz Shehzar Bashir Bilal Khan Tayyaba Ikram Qazi

Reported

Sample size8797

Disease-free survival hazard ratio0.68

Disease-free survival 95% CI0.60-0.76

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