AUG 17, 2026 · JOURNAL ARTICLE
Efficacy of SGLT2 inhibitors, GLP-1 receptor agonists, and aerobic exercise for moderate-to-severe obstructive sleep apnea in overweight or obese patients: a network meta-analysis
Frontiers in Endocrinology
A network meta-analysis of 15 trials (mostly RCTs) showing GLP-1 agonists reduce AHI and BMI versus placebo, but confidence is low-to-very-low across most estimates, indirect comparisons are non-significant, and the authors explicitly state findings are hypothesis-generating rather than a basis for firm recommendations.
Reported
Primary endpoint: AHI reduction,…−15.28 events/h
95% CI for AHI reduction−22.22 to −8.35
BMI reduction, GLP-1 agonists vs…−1.78 kg/m²