JUL 14, 2026 · JOURNAL ARTICLE
CRISPR/Cas9 screen identifies DCAF4 as a novel protector of hepatocellular carcinoma against brachytherapy via stress granule-dependent NRF2 activation
Cell Death and Disease
A mechanistic discovery from genome-wide screening identifying a novel pathway regulating oxidative stress in HCC, supported by preclinical models but lacking clinical efficacy data or human validation.
Study details
DesignGenome-wide CRISPR-Cas9 screen with integra…
InterventionDCAF4 targeting via CRISPR knockout and sma…
ComparatorNot specified; preclinical efficacy inferre…