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A single-centre retrospective cohort study identifying a nonlinear association between a novel composite biomarker and one-year mortality in ACS, with adequate sample size and hard endpoint, but limited by observational design and lack of external validation.
Observational cohort study with a large sample (4,800 patients) from a national database showing no benefit of prolonged DAPT on cardiovascular outcomes in ACS patients, but identifying a signal of increased bleeding in CKD subgroup; findings are exploratory and require confirmation.