AUG 14, 2026 · JOURNAL ARTICLE
Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy
Frontiers in Oncology
Sound experimental study in 3D models demonstrating that DNA damage response inhibitors enhance radiosensitivity to both X-rays and proton therapy, but limited to in vitro spheroids without clinical validation or human data.
Study details
DesignIn vitro experimental study using 3D sphero…
InterventionInhibition of ATM (AZD1390), ATR (AZD6738),…
ComparatorRadiation alone (X-rays or proton beam ther…