JUN 24, 2026 · JOURNAL ARTICLE
Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.
Experimental Neurology
Mechanistic study in transgenic mice identifying divergent microglial phenotypes between R47H variant and null mutation; no clinical endpoint or human validation provided.
Reported
Age at analysis18 or 24 months