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Indeevar Beeram

Johns Hopkins University

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AUG 17, 2026 · JOURNAL ARTICLE

Influence of GLP-1 Receptor Agonists on Surgical and Nonsurgical Treatment of Ankle Osteoarthritis

Foot & Ankle Specialist

Retrospective cohort study with propensity matching in a large registry showing differential effects of GLP-1 use on ankle OA interventions by metabolic phenotype, but limited by observational design, inability to control unmeasured confounding, and lack of mechanistic explanation for conflicting outcomes between cohorts.

PromisingLilia Elsabbagh Amiethab Aiyer Peripheral Artery Disease Management

Reported

Ankle joint injection risk in obe…HR = 0.8, 95% CI = 0.6–0.9

TAA risk in obese cohortHR = 0.5, 95% CI = 0.3–0.9

Arthroscopy risk in diabetic coho…HR = 1.9, 95% CI = 1.2–3.2

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