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Shahar Azar

Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD, USA.

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AUG 23, 2026 · JOURNAL ARTICLE

Natural microbiota confer life-long protection against obesity via an early-life, immune-mediated effect on brown adipocytes.

Gut Microbes

A mechanistic murine study with multi-faceted evidence (RNA sequencing, genetic knockouts, adoptive transfer) identifying a microbiota–immune pathway to obesity resistance, but limited by preclinical design and absence of human validation.

PromisingBarbara Rehermann Obesity Oksana Gavrilova

Study details

DesignPreclinical mechanistic study using multipl…

InterventionReconstitution with natural microbiota from…

ComparatorStandard laboratory microbiota (implied); S…

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