SEP 10, 2026 · JOURNAL ARTICLE
Increased Energy Expenditure through Intermittent Cold Exposure Does Not Enhance Tirzepatide Induced Weight-loss in Obese Mice
American Journal of Physiology-regulatory, Integrative and Comparative Physiology
Preclinical animal study testing a combination intervention hypothesis with negative primary outcome; results do not support additive benefit and require clinical translation.
Reported
Tirzepatide dose10 nmol/kg
Cold exposure temperature and dur…4°C, 1 h/day, 5 days/week for 3 weeks
Treatment duration3 weeks