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Matthew G. Oser

Dana-Farber Brigham Cancer Center

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AUG 18, 2026 · JOURNAL ARTICLE

Polycomb Scaffolding Subunit EED Supports the SCLC Neuroendocrine Identity and EGFR-Mutant LUAD to SCLC Transformation

Journal of Clinical Investigation

Mechanistic study in genetically engineered mouse models identifying EED as a regulator of SCLC identity and LUAD-to-SCLC transformation; lacks clinical trial data or human validation beyond xenograft correlation.

Hypothesis-GeneratingHyeonseo Cho Lung Cancer Research Studies Gabriel Roberti De Oliveira

Study details

DesignPreclinical mechanistic study using CRISPR-…

InterventionCRISPR-based inactivation of EED (PRC2 scaf…

ComparatorControl tumors with intact EED and PRC2 com…

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