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Yujie Peng

Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

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MAY 27, 2026 · JOURNAL ARTICLE

Lysosome-directed targeted protein degradation technologies for overcoming cancer drug resistance: mechanisms, design principles, and therapeutic opportunities.

Drug Delivery

A comprehensive review article synthesizing mechanistic principles and design strategies for an emerging therapeutic modality (LYTACs) in preclinical and early translational stages, with no primary experimental data or clinical trial results.

Expert GuidanceYing Zhang Mingqi Liu Huixin Mao

Reported

Endocrine therapy resistance rate…approximately 30% within 5 years

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