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Megan Breckheimer

Johns Hopkins University

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AUG 14, 2026 · JOURNAL ARTICLE

SHORT- VERSUS LONG-COURSE RADIATION IN TOTAL NEOADJUVANT THERAPY FOR LOCALLY ADVANCED RECTAL CANCER: A PROPENSITY-MATCHED NATIONAL CANCER DATABASE ANALYSIS

Diseases of the Colon & Rectum

Retrospective propensity-matched cohort study showing no difference in overall survival between radiation regimens in total neoadjuvant therapy for rectal cancer, confirming equipoise between approaches already in clinical use.

Important Confirmatory EvidenceMiloslawa Stem John Migaly James J. Whitbread

Reported

Sample size (matched cohort)1,721 per group

Long course radiation (overall co…10,740 (86.2%)

Short course radiation (overall c…1,722 (13.8%)

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