AUG 14, 2026 · JOURNAL ARTICLE
Antipsychotic medication and the prevention of psychiatric emergencies in difficult-to-treat adolescent depression.
Journal of Affective Disorders
Large observational cohort study with propensity-score weighting comparing antipsychotics to antidepressants for a hard clinical outcome (psychiatric emergency visits/admissions) in adolescents with difficult-to-treat depression, showing increased risk with antipsychotics and consistent results across sensitivity analyses.
Reported
Hazard ratio (antipsychotic vs. a…1.59
95% CI for hazard ratio1.46, 1.72
Cumulative incidence, antipsychot…38.7%