JUL 28, 2026 · JOURNAL ARTICLE
Dual Cholinesterase Inhibition and Antimicrobial Activity of 4-Aminoantipyrine-Derived Schiff Bases for the Management of Alzheimer’s Disease and Microbial Infections
Russian Journal of Bioorganic Chemistry
This is an early-stage chemical synthesis and in vitro screening study with no animal or clinical data; it raises the question whether these compounds merit further development but does not yet answer whether they are safe or effective in disease.
Reported
AChE IC50 (PSD2)2.71 µM
AChE IC50 (galantamine reference)20.3 µM
AChE selectivity ratio (PSD2)10.62