FEB 3, 2026 · JOURNAL ARTICLE
HIV expression persists in the cerebrospinal fluid of HIV-associated neurocognitive disorders despite effective ART.
Emerging Microbes & Infections
Cross-sectional study showing HIV RNA and derived peptides persist in cerebrospinal fluid of HAND patients despite undetectable plasma viral load and adequate ART penetration, suggesting latent infection may drive neuroinflammation, but lacks comparator group and causal evidence.
Reported
Sample size24
HAND participants14
Cognitively normal participants10