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Chen-Zhi Zhang

Departments of Colorectal Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, China.

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AUG 24, 2026 · JOURNAL ARTICLE

Body mass index and dyslipidemia influence responses to anti-PD-1 immunotherapy in colorectal cancer.

Annals of Medicine

A retrospective single-centre cohort study identifies BMI and dyslipidemia as associations with improved PFS in anti-PD-1-treated CRC, supported by exploratory lipidomic profiling, but lacks a control arm and prospective design to establish causation or clinical utility.

PromisingShi-Hong Chen Obesity Wu Jiang

Reported

Sample size142

BMI threshold for improved PFS≥24 kg/m²

p-value for PFS difference by BMI0.001

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