SEP 9, 2026 · JOURNAL ARTICLE
Checkpoint kinase 2 deficiency affects the engagement of DNA double-strand break repair pathways following DNA damage
Cell Death Discovery
A mechanistic study in cell lines showing how CHK2 deficiency alters DNA repair pathway engagement; findings are exploratory and require further investigation to establish clinical relevance.
Study details
DesignIn vitro mechanistic study using isogenic c…
InterventionCHK2 knockout (genetic) and pathway inhibit…
ComparatorCHK2 wild-type isogenic cells; ionizing rad…