AUG 13, 2026 · REVIEW
THE ROLE OF FLOT TOTAL NEOADJUVANT CHEMOTHERAPY REGIMEN IN PATIENTS WITH LOCALLY ADVANCED ADENOCARCINOMA OF THE STOMACH AND GASTROESOPHAGEAL JUNCTION. A NARRATIVE REVIEW
Clinical and Preventive Medicine
A narrative review synthesizing evidence from key trials (MAGIC, FLOT4, NeoFLOT, ESOPEC) to evaluate FLOT regimen efficacy in locally advanced gastric and GEJ adenocarcinoma, concluding perioperative chemotherapy remains standard of care but TNT is promising pending long-term survival data.
Reported
Pathological complete response ra…threefold
R0 resection rate (NeoFLOT)86%
pCR rate (NeoFLOT)20%